Manchester United had a luckless night in their Champions League opener as Luke Shaw suffered a suspected broken leg amid defeat by PSV Eindhoven.
Shaw was chopped down by Hector Moreno before being carried off early on.
After a long delay, Memphis Depay scored a weaving opener on his return to PSV, but in first-half injury time Moreno headed in from a corner.
PSV's Luciano Narsingh headed in a 57th-minute winner despite United dominating for long periods.
Unlike previous games this season where Louis van Gaal's side have struggled to turn their superiority into chances, they chalked up 17 shots on goal to PSV's six.
There were encouraging displays from Depay, who scored his third of the season, and Anthony Martial, who made his full debut following his wonder goal during the win over Liverpool last Saturday.
Poor finishing let the visitors down, although their biggest concern will be over Shaw who looks likely to suffer a lengthy lay-off.
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